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dc.contributor.authorDalivelya, Olga-
dc.contributor.authorДаливеля, Ольга Вячеславовна-
dc.date.accessioned2016-02-15T07:51:28Z-
dc.date.available2016-02-15T07:51:28Z-
dc.date.issued2006-
dc.identifier.urihttp://elib.bspu.by/handle/doc/10225-
dc.description.abstractIn a series of studies it was shown that 1,4-dihydropyridine derivatives (1,4-DHP) show antimutagenic and anticlastogenic properties and accelerate repair of oxidant and ionising radiation generated DNA damage. Here, effects of one of 1,4-DHP compounds (sodium 3,5-bis-ethoxycarbonyl-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate denoted as DHP) in X-irradiated L5178Y cells (murine lymphoma sublines, LY-R and LY-S) are reported. DHP treatment 1 h before, during and after X-irradiation gave a radioprotective effect in double strand break (DSB) repair competent LY-R cells: there was an increase in post-irradiation proliferation and cell viability as well as a slight acceleration of break rejoining as measured by the neutral comet assay. In the radiosensitive LY-S cells with impaired non-homologous end-joining system, the radioprotective effect was seen as enhanced growth and viability. There was, however, no effect on the DSB repair rate. Notably, there was no dependence of the biological effects on DHP concentration in the range of concentrations studied (1 nM − 100 µM), suggesting an all-or-none effect, as in cellular signaling induction observed in radioadaptation or bystander effect. We assume that DHP acts by decreasing fixation of radiation inflicted DNA damage, among others, by increasing the rate of DNA repair and enhancing the efficiency of checkpoint control. Direct confirmation of this assumption is necessary.ru_RU
dc.relation.ispartofseriesNUKLEONIKA;vol. 51(3)-
dc.subjectБГПУru_RU
dc.subject1,4-dihydropyridineru_RU
dc.subjectDNA repairru_RU
dc.subjectneutral comet assayru_RU
dc.subjectL5178Y cellsru_RU
dc.subjectcytotoxicityru_RU
dc.subjectradioprotective effectru_RU
dc.titleEffects of an antimutagen of 1,4-dihydropyridine series on cell survival and DNA damage in L5178Y murine sublinesru_RU
dc.typeArticleru_RU
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