Single nucleotide polymorphism genotyping using DNA sequencing on multiwalled carbon nanotubes monolayer by CNT-plasmon resonance

Abstract

DNA-nanosensor based on multiwalled carbon nanotubes (MWCNTs) decorated by nanocyclic thiophene-pyrrole complexes of octahedral high-spin Fe has been proposed for high-performance sensing of DNA-hybridization utilizing a surface-enhanced spin- dependent CNT-plasmon resonance. This DNA-nanosensor operates on screening and quenching e ects at Raman scattering of light in duplexes DNA-probe/DNA-target at complementary pairing of nucleotides in DNA. Single nucleotide polymorphism (SNP) genotyping has been successfully performed for DNA samples from healthy and cancer- su ering donors.