Effects of an antimutagen of 1,4-dihydropyridine series on cell survival in X-irradiated murine L5178Y Sublines

Abstract

Theses has shown that some derivatives of 1,4-dihydropyridine (1,4-DHP) DHP and glutapyrone, can modulate DNA repair resulting in reduction in the frequency of EMS-induced chromosome breakage and point mutations. DHP increased both the background and radiation-induced level of cell viability in LY–S cells and did not affect this parameter in LY–R cells.